These have been described as giant cells with budding nuclei (Bizzozero [2]); but it seems to me that they are worthy of a more distinctive name. I shall speak of them hereafter as megakaryocytes, or large nucleated giant cells, while the first class might be named polykaryocytes, or multinucleated giant cells.

The evidence of formation of blood platelets from the megakaryocyte is conclusive. Except for the origin of platelets in the early embryo from a forerunner of the megakaryocyte, Wright recognizes no other source for blood platelets in mammals.

Under appropriate culture conditions, the megakaryocyte burst-forming cell can develop into 40 to 500 megakaryocytes within 1 week.

Megakaryocyte

Meaning

Noun

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