Comparison of the sequences of the various osteocalcins indicates that the central portion of the molecule is highly conserved.

Osteocalcin has recently been identified as a bone-derived hormone with significant functional impacts on sex steroid production by the testis, completing the circle of mutual interdependence between the skeletal system and gonad (for reviews, see Refs 536–538).

Osteocalcin together with the other Gla-protein MGP belongs to a distinct subgroup of the larger vitamin K-dependent protein family, the constituents of which are primarily involved in blood coagulation.

Osteocalcin

Meaning

Noun

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