A CRF antagonist, -helical CRF(9-41), can also attenuate the anxiogenic behavioral effects of HU-210.

Increases in dopamine efflux in the NAS cannot simply be seen as equivalent to drug reward, because aversive stimuli, such as foot shock, and anxiogenic drugs, such as FG 7142 and beta-CCE (which are not self-administered), have exactly the same neurochemical effect (3 ).

Central injection of substance P or related peptide agonists induces conditioned place aversion and produces an anxiogenic profile on the elevated plus maze, implying that activation of central substance P pathways is aversive (5 ).

Thus, self-directed behavior increases after anxiogenic drug treatment but decreases after anxiolytic drug treatment (29 ).

This piece will perform a micro-excavation of these toplayers of the literary soil to suggest anxiogenic literature has the potential not only to adumbrate the post-apocalypse, a common theme in contemporary literature, but also to anticipate the post-Anthropocene.

Anxiogenic

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